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Haemophilia What Is Haemophilia? Haemophilia is a rare inherited bleeding disorder in which the blood does not clot normally. Persons with haemophilia...
Haemophilia is an inherited bleeding disorder which is usually occurs in male only.
What Is Haemophilia?
Haemophilia is a rare inherited bleeding disorder in which the blood does not clot normally. Persons with haemophilia may bleed for a longer time than others after an injury or accident. They also may bleed internally, especially in the joints (knees, ankles, and elbows).
Babies born with haemophilia are missing or have a low level of a protein needed for normal blood clotting or blood coagulation. The protein is called a clotting factor.
Haemophilia usually occurs only in males (with very rare exceptions).
An expert describes the different types of haemophilia, a genetic condition that affects the bloods ability to clot.
Haemophilia, also known as other translations including: hémophilie, hemofilie, hemofili, hemofilia, hämophilie, emofilia, is a rare blood disorder caused by an inherited gene that results in the blood does not clot properly.
People with haemophilia lack one of the essential blood clotting factors. It is mainly a male disorder because the haemophilia gene is carried on the X chromosome. However it can occur in any family. People with haemophilia need special first aid for injured muscles or joints.Hemophilia Types There are two main types of hemophilia – Hemophilia A (due to factor VIII deficiency) and Hemophilia B (due to factor IX deficiency). They are clinically almost identical and are associated with spontaneous bleeding into...
Hemophilia is nearly always caused by a genetic error causing the lack of a normally functioning clotting factor:
- Hemophilia A involves a lack of functional clotting Factor VIII.
- Hemophilia B involves a lack of functional clotting Factor IX.
- Hemophilia C involves a lack of functional clotting Factor XI.
- Hypofibrinogenemia involves a lack of functional clotting Factor I.
What are the symptoms?
The symptoms are highly variable, and their severity depends on how much Factor VIII or IX is produced. They usually develop in infancy and may include:
- Easy bruising even after minor injury.
- Sudden, painful swelling of muscles and joints due to internal bleeding.
- Prolonged bleeding after an injury or a minor surgical operation.
- Blood in the urine.
Without treatment, prolonged episodes of bleeding into the joints may result in long-term damage and, eventually, may lead to deformity of the joints.
Haemophilia is treated using a comprehensive care model. Comprehensive care clinics provide all the medical services needed by the person with haemophilia and their family for the treatment of haemophilia and related conditions. The comprehensive care team consists of a haematologist, nurse coordinator, physiotherapist and outreach worker with specific expertise in managing the healthcare needs of persons with bleeding disorders.
Bleeds of people with haemophilia are treated by replacing the missing clotting factor in the blood. Bleeding stops when enough clotting factor reaches the bleeding site. It is very important that treatment is given as quickly as possible for joint bleeds to prevent long-term damage
Information About Leukemia
There's no cure for haemophilia and, although patients are treated with injections of the missing clotting factor, there's no permanent way of increasing its level.
So the mainstay of treatment is replacement of the missing clotting factor. This is known as replacement therapy and these days, in most countries including the UK, it usually consists of injections of concentrates of artificially produced clotting factors (made using recombinant technology, rather the old method of extracting the clotting factors from donated blood).
In severe haemophilia injections may be given on a regular basis several times a week. This is called prophylaxis, and it aims to help prevent bleeding from happening. In mild...
Leukemia refers to cancers of the white blood cells (also called leukocytes or WBCs). With the proper treatment, the outlook for kids who are diagnose...
Leukemia is a cancer of the blood cells or bone marrow with numerous types and classifications.
- Leukemia — from the Greek word “leukos”, meaning “clear or white”, and “haima or emia” which refers to blood — is a broad term covering a disease which is characterized by an abnormal production of anomalous white blood cells. It is a cancer of the blood cells or bone marrow with numerous types and classifications. Leukemia usually comes from cells of the myeloid system that are made in the bone marrow. When tumor cells are found in the circulating blood, by definition, it is leukemia.
Types of Leukemia
There are different types of leukemia, which are broken down into two main groups, acute and chronic. The two types under acute leukemia are:
acute lymphoblastic leukemia (ALL) acute myelogenous leukemia (AML)
Chronic leukemia groups are:
chronic lymphocytic leukemia (CLL) acute myelogenous leukemia (AML)
Types of acute leukaemia
Acute leukaemia is classified according to the type of white blood cells that are affected by cancer. There are two main types of white blood cell:
- lymphocytes – which are mostly used to fight viral infections
- myeloid cells – which perform a number of different functions, such as fighting bacterial infections, defending the body against parasites and preventing the spread of tissue damage
There are two main types of acute leukaemia that are related to the two main types of white blood cells. They are:
Common symptoms of Leukemia are weight loss, fever, fatigue and loss appetite. Easy shortness of breath and swelling. Muscular reakness, bones or joints pain or tenderness. Also, easy bleeding and bruising.
- Here are information about What factors causing leukemia cells. Leukaemia is a malignant tumor of leucocyte (leucocytes) are characterised by an abnormal step up in WBC in the blood stream. The happening of the product of white cell that are still untried with a tight, redundant, and do not work. These cells are reformist pass through into the dead body tissues paper, especially in the bone marrow. This resulted in the bone marrow is damaged and loses its mapping to make erythrocyte (rbcs), normal white corpuscle, and bloods platelet. As a result of the failure to make RBC so can lead to anemia. The want of leukocyte can lead to a decrement in granting immunity to infection and vitiating the product of bloods platelet which can cause hemorrhage. Essentially, there are four types of leucaemia, chronic lymphocytic leukemia is incisive, piercing...
Certain chemical reaction is also the possible causes of Leukemia. If you are exposed to high levels of benzene everyday in your workplace, you will be most likely to develop Leukemia and the worse part is, benzene is a widely used chemical in the chemical industry. It is advisable that you go for routine check up if you are working in this line. Formaldehyde, another widely used chemical type in the chemical industry also known to cause Leukemia due to the long term exposure of your body to it.
Leukemia in children maybe caused by a genetic misfortune. Some children who are born with down syndrome...
Leukemia-Treatment-and-TherapyThese new article about New Leukemia Treatment and Therapy. As we know that Leukemia is cancer of the blood cells that starts in the bone marrow, the soft tissue inside most bones, where blood cells are made. New approach for treating leukemia turning the patients’ own blood cells into assassins that hunt and destroy their cancer cells. Gene therapy shown to destroy leukemia tumors. New research from Scientists at the University of Pennsylvania find protein called CD-19 found on leukemia cells and a phase I trial has shown they destroy cancer cells in patients with chronic lymphocytic leukemia (CLL). Available experimental treatment for leukemia could represent a breakthrough, and one that might bode well for the treatment of other cancers.
- Allogeneic bone marrow transplantation, through donor lymphocyte infusion (DLI), is commonly used in the treatment of leukemia and lymphoma. Although it is an effective therapy, graft versus host disease is seen in 30-50% of patients. This side-effect is the result of transplanted T cells from the donor attacking normal tissue as well as the target leukemia or lymphoma cells. GVHD is difficult to treat and has a mortality rate of 15-30%. As few treatment options are available, this represents a disease with high unmet therapeutic need.
- Treatments for leukemia As the various types of leukemias affect patients differently, their treatments depend on what type of leukemia they have. The type of treatment will also depend on the patient's age and his state of health. In order to get the most effective treatment the patient should get treatment at a center where doctors have experience and are well trained in treating leukemia patients. As treatment has improved, the aim of virtually all health care professionals should be complete remission - that the cancer goes away completely for a minimum of five years after treatment.
Treatments for Leukemia
Treating people with leukemia is very challenging. Because these are blood cells, leukemia cells are found throughout the body. Therefore, surgery alone cannot be used to treat this disease. Both blood and bone marrow tests allow doctors to diagnose leukemia.
Chemotherapy is the most effective method of leukemia cancer treatment. Various anticancer drugs are used, usually in combination. In general, treatment for AML uses higher doses of chemotherapy over a shorter period of time. Treatment for ALL involves lower doses of chemotherapy over a longer period of time.
CML is one of the great recent success stories in cancer therapy. Knowing the exact genetic change in CML allowed doctors to design a drug to combat it. This "leukemia pill," called Gleevec, has revolutionized...